› 2lxw

Solution NMR

The solution structure of XIAP(RING)-binding domain of human XAF1

Released:
DOI: 10.2210/pdb2lxw/pdb
PDB entry 2lxw coloured by chain, ensemble of 15 models, front view.
PDB entry 2lxw coloured by chain, ensemble of 15 models, side view.
PDB entry 2lxw coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Entry authors: Tse M, Cho C, Guan X, Sze K

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179710 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
XIAP-associated factor 1 Chain: A
Molecule details ›
Chain: A
Length: 55 amino acids
Theoretical weight: 6.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6GPH4 (Residues: 251-301; Coverage: 17%)
Gene names: BIRC4BP, XAF1, XIAPAF1
Sequence domains: XIAP-associated factor 1 C-terminal domain
Structure domains: Single alpha-helices involved in coiled-coils or other helix-helix interfaces

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: molecular dynamics
Expression system: Escherichia coli

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