› 2lz4

Solution NMR

Solution NMR structure of transmembrane domain of amyloid precursor protein V44M

Released:
DOI: 10.2210/pdb2lz4/pdb
PDB entry 2lz4 coloured by chain, ensemble of 21 models, front view.
PDB entry 2lz4 coloured by chain, ensemble of 21 models, side view.
PDB entry 2lz4 coloured by chain, ensemble of 21 models, top view.
Source organism: Homo sapiens
Primary publication:
Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site.
Chen W, Gamache E, Rosenman DJ, Xie J, Lopez MM, Li YM, Wang C
Nat Commun 5 3037 (2014)
PMID: 24390130

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(42) Chains: A, B
Molecule details ›
Chains: A, B
Length: 31 amino acids
Theoretical weight: 3.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05067 (Residues: 699-726; Coverage: 4%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 48%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

10 review citations

Interplay of endoplasmic reticulum stress and autophagy in neurodegenerative disorders.
Cai et al. (2016)
9 more

2 mentions without citation

Alzheimer's disease--a panorama glimpse.
Zhao et al. (2014)
1 more