› 2m16

Solution NMR

P75/LEDGF PWWP Domain

Released:
DOI: 10.2210/pdb2m16/pdb
PDB entry 2m16 coloured by chain, ensemble of 20 models, front view.
PDB entry 2m16 coloured by chain, ensemble of 20 models, side view.
PDB entry 2m16 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for high-affinity binding of LEDGF PWWP to mononucleosomes.
Eidahl JO, Crowe BL, North JA, McKee CJ, Shkriabai N, Feng L, Plumb M, Graham RL, Gorelick RJ, Hess S, Poirier MG, Foster MP, Kvaratskhelia M
Nucleic Acids Res 41 3924-36 (2013)
PMID: 23396443

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130985 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
PC4 and SFRS1-interacting protein Chain: A
Molecule details ›
Chain: A
Length: 97 amino acids
Theoretical weight: 11.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75475 (Residues: 1-93; Coverage: 18%)
Gene names: DFS70, LEDGF, PSIP1, PSIP2
Sequence domains: PWWP domain
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 69%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

47 review citations

Epigenetic modifications of histones in cancer.
Zhao et al. (2019)
46 more

5 mentions without citation

PWWP domains and their modes of sensing DNA and histone methylated lysines.
Rona et al. (2016)
4 more