› 2m1x

Solution NMR

TICAM-1 TIR domain structure

Released:
DOI: 10.2210/pdb2m1x/pdb
PDB entry 2m1x coloured by chain, ensemble of 20 models, front view.
PDB entry 2m1x coloured by chain, ensemble of 20 models, side view.
PDB entry 2m1x coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling.
Enokizono Y, Kumeta H, Funami K, Horiuchi M, Sarmiento J, Yamashita K, Standley DM, Matsumoto M, Seya T, Inagaki F
Proc Natl Acad Sci U S A 110 19908-13 (2013)
PMID: 24255114

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-184848 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TIR domain-containing adapter molecule 1 Chain: A
Molecule details ›
Chain: A
Length: 168 amino acids
Theoretical weight: 19.13 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8IUC6 (Residues: 387-545; Coverage: 22%)
Gene names: PRVTIRB, TICAM1, TRIF
Structure domains: Toll/interleukin-1 receptor homology (TIR) domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: torsion angle dynamics, simulated annealing
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Innate immune pattern recognition: a cell biological perspective.
Brubaker et al. (2015)
9 more

4 mentions without citation

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling.
Ve et al. (2017)
3 more