› 2m5n

Solid-state NMR

Atomic-resolution structure of a cross-beta protofilament

Released:
DOI: 10.2210/pdb2m5n/pdb
PDB entry 2m5n coloured by chain, ensemble of 20 models, front view.
PDB entry 2m5n coloured by chain, ensemble of 20 models, side view.
PDB entry 2m5n coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Atomic structure and hierarchical assembly of a cross-β amyloid fibril.
Fitzpatrick AW, Debelouchina GT, Bayro MJ, Clare DK, Caporini MA, Bajaj VS, Jaroniec CP, Wang L, Ladizhansky V, Müller SA, MacPhee CE, Waudby CA, Mott HR, De Simone A, Knowles TP, Saibil HR, Vendruscolo M, Orlova EV, Griffin RG, Dobson CM
Proc Natl Acad Sci U S A 110 5468-73 (2013)
PMID: 23513222

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo hexadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136166 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P
Length: 11 amino acids
Theoretical weight: 1.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P02766 (Residues: 125-135; Coverage: 9%)
Gene names: PALB, TTR

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 3%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

75 review citations

The amyloid state and its association with protein misfolding diseases.
Knowles et al. (2014)
74 more

11 mentions without citation

Proteins Do Not Replicate, They Precipitate: Phase Transition and Loss of Function Toxicity in Amyloid Pathologies.
Ezzat et al. (2022)
10 more