› 2m6z

Solution NMR

Refined solution structure of Human Adult Hemoglobin in the Carbonmonoxy Form

Released:
DOI: 10.2210/pdb2m6z/pdb
PDB entry 2m6z coloured by chain, ensemble of 20 models, front view.
PDB entry 2m6z coloured by chain, ensemble of 20 models, side view.
PDB entry 2m6z coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure and dynamics of human hemoglobin in the carbonmonoxy form.
Fan JS, Zheng Y, Choy WY, Simplaceanu V, Ho NT, Ho C, Yang D
Biochemistry 52 5809-20 (2013)
PMID: 23901897

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159519 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Hemoglobin subunit alpha Chains: A, C
Molecule details ›
Chains: A, C
Length: 141 amino acids
Theoretical weight: 15.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P69905 (Residues: 2-142; Coverage: 99%)
Gene names: HBA1, HBA2
Sequence domains: Globin
Structure domains: Globins
Hemoglobin subunit beta Chains: B, D
Molecule details ›
Chains: B, D
Length: 146 amino acids
Theoretical weight: 15.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P68871 (Residues: 2-147; Coverage: 99%)
Gene name: HBB
Sequence domains: Globin
Structure domains: Globins

Ligands and Environments

1 bound ligand:
Ligand HEM 4 x HEM
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 37%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Hemoglobin: Structure, Function and Allostery.
Ahmed et al. (2020)
1 more

9 mentions without citation

New look at hemoglobin allostery.
Yuan et al. (2015)
8 more