› 2m7p

Solution NMR

RXFP1 utilises hydrophobic moieties on a signalling surface of the LDLa module to mediate receptor activation

Released:
DOI: 10.2210/pdb2m7p/pdb
PDB entry 2m7p coloured by chain, ensemble of 20 models, front view.
PDB entry 2m7p coloured by chain, ensemble of 20 models, side view.
PDB entry 2m7p coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation.
Kong RC, Petrie EJ, Mohanty B, Ling J, Lee JC, Gooley PR, Bathgate RA
J Biol Chem 288 28138-51 (2013)
PMID: 23926099

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134042 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Low-density lipoprotein receptor; Relaxin receptor 1 Chain: A
Molecule details ›
Chain: A
Length: 42 amino acids
Theoretical weight: 4.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HBX9 (Residues: 25-25, 28-40; Coverage: 2%)
  • Canonical: P01130 (Residues: 67-68, 83-104; Coverage: 3%)
Gene names: LDLR, LGR7, RXFP1
Sequence domains: Low-density lipoprotein receptor domain class A
Structure domains: Low-density Lipoprotein Receptor

Ligands and Environments

1 bound ligand:
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli

Quick links

Citations

4 review citations

International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.
Halls et al. (2015)
3 more

1 mention without citation

The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation.
Kong et al. (2013)