› 2maj

Solution NMR

Solution Structure of the STIM1 CC1-CC2 homodimer.

Released:
DOI: 10.2210/pdb2maj/pdb
PDB entry 2maj coloured by chain, ensemble of 20 models, front view.
PDB entry 2maj coloured by chain, ensemble of 20 models, side view.
PDB entry 2maj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry.
Stathopulos PB, Schindl R, Fahrner M, Zheng L, Gasmi-Seabrook GM, Muik M, Romanin C, Ikura M
Nat Commun 4 2963 (2013)
PMID: 24351972

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171770 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stromal interaction molecule 1 Chains: A, C
Molecule details ›
Chains: A, C
Length: 82 amino acids
Theoretical weight: 9.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13586 (Residues: 312-387; Coverage: 12%)
Gene names: GOK, STIM1
Sequence domains: STIM1 Orai1-activating region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 43%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

46 review citations

Store-Operated Calcium Channels.
Prakriya et al. (2015)
45 more

6 mentions without citation

Structural and functional mechanisms of CRAC channel regulation.
Shim et al. (2015)
5 more