› 2mcg

X-ray diffraction
2Å resolution

THREE-DIMENSIONAL STRUCTURE OF A LIGHT CHAIN DIMER CRYSTALLIZED IN WATER. CONFORMATIONAL FLEXIBILITY OF A MOLECULE IN TWO CRYSTAL FORMS

Released:
DOI: 10.2210/pdb2mcg/pdb
PDB entry 2mcg coloured by chain, front view.
PDB entry 2mcg coloured by chain, side view.
PDB entry 2mcg coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms.
Ely KR, Herron JN, Harker M, Edmundson AB
J Mol Biol 210 601-15 (1989)
PMID: 2515285

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134491 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Immunoglobulin lambda variable 2-8 Chains: 1, 2
Molecule details ›
Chains: 1, 2
Length: 216 amino acids
Theoretical weight: 22.83 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01709 (Residues: 20-118; Coverage: 100%)
Gene name: IGLV2-8
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands
1 modified residue:
Ligand PCA 2 x PCA

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3121
Unit cell:
a: 72.3Å b: 72.3Å c: 185.9Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 not available not available
Expression system: Not provided

Quick links

Citations

9 review citations

Anatomy of the antibody molecule.
Padlan EA. (1994)
8 more

5 mentions without citation

A complete, multi-level conformational clustering of antibody complementarity-determining regions.
Nikoloudis et al. (2014)
4 more