› 2mdf

Solution NMR

NMR structure of a two-transmembrane segment TM VI-VII of NHE1

Released:
DOI: 10.2210/pdb2mdf/pdb
PDB entry 2mdf coloured by chain, ensemble of 25 models, front view.
PDB entry 2mdf coloured by chain, ensemble of 25 models, side view.
PDB entry 2mdf coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural and functional analysis of the transmembrane segment pair VI and VII of the NHE1 isoform of the Na+/H+ exchanger.
Alves C, Lee BL, Sykes BD, Fliegel L
Biochemistry 53 3658-70 (2014)
PMID: 24840010

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148672 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sodium/hydrogen exchanger 1 Chain: A
Molecule details ›
Chain: A
Length: 57 amino acids
Theoretical weight: 6.26 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P19634 (Residues: 226-274; Coverage: 6%)
Gene names: APNH1, NHE1, SLC9A1
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 52%
Refinement method: simulated annealing
Expression system: Escherichia coli

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Citations

2 review citations

Structure and function of yeast and fungal Na+ /H+ antiporters.
Dutta et al. (2018)
1 more