› 2mh9

Solution NMR

Resonance assignment of RQC domain of human Bloom syndrome protein

Released:
DOI: 10.2210/pdb2mh9/pdb
PDB entry 2mh9 coloured by chain, ensemble of 10 models, front view.
PDB entry 2mh9 coloured by chain, ensemble of 10 models, side view.
PDB entry 2mh9 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein.
Park CJ, Ko J, Ryu KS, Choi BS
J Biomol NMR 58 141-7 (2014)
PMID: 24435566

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156943 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RecQ-like DNA helicase BLM Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P54132 (Residues: 1067-1210; Coverage: 10%)
Gene names: BLM, RECQ2, RECQL3
Sequence domains: RQC domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

G-quadruplexes and helicases.
Mendoza et al. (2016)
1 more

1 mention without citation

Recognition and Unfolding of c-MYC and Telomeric G-Quadruplex DNAs by the RecQ C-Terminal Domain of Human Bloom Syndrome Helicase.
Lee et al. (2020)