› 2mji

Solution NMR

HIFABP_Ketorolac_complex

Released:
DOI: 10.2210/pdb2mji/pdb
PDB entry 2mji coloured by chain, ensemble of 10 models, front view.
PDB entry 2mji coloured by chain, ensemble of 10 models, side view.
PDB entry 2mji coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Characterization of two distinct modes of drug binding to human intestinal fatty acid binding protein.
Patil R, Laguerre A, Wielens J, Headey SJ, Williams ML, Hughes ML, Mohanty B, Porter CJ, Scanlon MJ
ACS Chem Biol 9 2526-34 (2014)
PMID: 25144524

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146097 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fatty acid-binding protein, intestinal Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P12104 (Residues: 2-132; Coverage: 99%)
Gene names: FABP2, FABPI
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

1 bound ligand:
Ligand KTR 1 x KTR
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 75%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Polarity-based fluorescence probes: properties and applications.
Qin et al. (2021)
1 more

1 mention without citation

Rosetta:MSF: a modular framework for multi-state computational protein design.
Löffler et al. (2017)