› 2mk2

Solution NMR

Solution NMR structure of N-terminal domain (SH2 domain) of human Inositol polyphosphate phosphatase-like protein 1 (INPPL1) (fragment 20-117), Northeast Structural Genomics Consortium Target HR9134A

Released:
DOI: 10.2210/pdb2mk2/pdb
PDB entry 2mk2 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mk2 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mk2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Yang Y, Ramelot TA, Janjua H, Xiao R, Everett JK, Montelione GT, Kennedy MA, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Reaction catalysed: 
1-phosphatidyl-1D-myo-inositol 3,4,5-triphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3,4-diphosphate + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127447 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 12.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15357 (Residues: 20-117; Coverage: 8%)
Gene names: INPPL1, SHIP2
Sequence domains: SH2 domain
Structure domains: SH2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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