› 2mov

Solution NMR

Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal Derived AGEs.

Released:
DOI: 10.2210/pdb2mov/pdb
PDB entry 2mov coloured by chain, ensemble of 20 models, front view.
PDB entry 2mov coloured by chain, ensemble of 20 models, side view.
PDB entry 2mov coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The receptor for advanced glycation end products (RAGE) specifically recognizes methylglyoxal-derived AGEs.
Xue J, Ray R, Singer D, Böhme D, Burz DS, Rai V, Hoffmann R, Shekhtman A
Biochemistry 53 3327-35 (2014)
PMID: 24824951

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172192 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Advanced glycosylation end product-specific receptor Chain: A
Molecule details ›
Chain: A
Length: 105 amino acids
Theoretical weight: 11.57 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15109 (Residues: 23-125; Coverage: 27%)
Gene names: AGER, RAGE
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand IOR 1 x IOR
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

25 review citations

The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases.
Maessen et al. (2015)
24 more

8 mentions without citation

Advanced Glycation End Products in Health and Disease.
Reddy et al. (2022)
7 more