› 2mpg

Solution NMR

Solution structure of the [AibB8,LysB28,ProB29]-insulin analogue

Released:
DOI: 10.2210/pdb2mpg/pdb
PDB entry 2mpg coloured by chain, ensemble of 35 models, front view.
PDB entry 2mpg coloured by chain, ensemble of 35 models, side view.
PDB entry 2mpg coloured by chain, ensemble of 35 models, top view.
Source organism: Homo sapiens
Primary publication:
Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin.
Kosinová L, Veverka V, Novotná P, Collinsová M, Urbanová M, Moody NR, Turkenburg JP, Jiráček J, Brzozowski AM, Žáková L
Biochemistry 53 3392-402 (2014)
PMID: 24819248

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134182 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Insulin A chain Chain: A
Molecule details ›
Chain: A
Length: 21 amino acids
Theoretical weight: 2.38 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 90-110; Coverage: 24%)
Gene name: INS
Insulin B chain Chain: B
Molecule details ›
Chain: B
Length: 30 amino acids
Theoretical weight: 3.46 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01308 (Residues: 25-54; Coverage: 35%)
Gene name: INS
Sequence domains: Insulin/IGF/Relaxin family

Ligands and Environments

No bound ligands
1 modified residue:
Ligand AIB 1 x AIB

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 51%
Refinement method: torsion angle dynamics, molecular dynamics
Expression system: Not provided

Quick links

Citations

2 review citations

Progress in Simulation Studies of Insulin Structure and Function.
Gorai et al. (2022)
1 more