Function and Biology Details
Reaction catalysed:
S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130981 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MLL cleavage product N320; PC4 and SFRS1-interacting protein
Molecule details ›
Chain: A
Length: 164 amino acids
Theoretical weight: 18.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Lens epithelium-derived growth factor (LEDGF)
Length: 164 amino acids
Theoretical weight: 18.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q03164 (Residues: 110-160; Coverage: 1%) - Canonical: O75475 (Residues: 337-442; Coverage: 20%)
Sequence domains: Lens epithelium-derived growth factor (LEDGF)
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Chemical shift assignment:
71%
Refinement method:
simulated annealing
Expression system: Escherichia coli
