Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
hetero trimer (preferred)
Assembly name:
Integrin alphaIIb-beta3 complex and Filamin-A (preferred)
PDBe Complex ID:
PDB-CPX-138442 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Filamin-A
Molecule details ›
Chain: A
Length: 95 amino acids
Theoretical weight: 9.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins
Length: 95 amino acids
Theoretical weight: 9.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P21333 (Residues: 2236-2330; Coverage: 4%)
Sequence domains: Filamin/ABP280 repeat
Structure domains: Immunoglobulins
Integrin alpha-IIb light chain, form 2
Molecule details ›
Chain: B
Length: 21 amino acids
Theoretical weight: 2.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Integrin alpha cytoplasmic region
Length: 21 amino acids
Theoretical weight: 2.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P08514 (Residues: 1019-1039; Coverage: 2%)
Sequence domains: Integrin alpha cytoplasmic region
Integrin beta-3
Molecule details ›
Chain: C
Length: 47 amino acids
Theoretical weight: 5.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Integrin beta cytoplasmic domain
Length: 47 amino acids
Theoretical weight: 5.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P05106 (Residues: 742-788; Coverage: 6%)
Sequence domains: Integrin beta cytoplasmic domain
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Chemical shift assignment:
71%
Refinement method:
simulated annealing
Expression system: Escherichia coli
