› 2mul

Solution NMR

Solution Structure of the UBM1 domain of human HUWE1/ARF-BP1

Released:
DOI: 10.2210/pdb2mul/pdb
PDB entry 2mul coloured by chain, ensemble of 20 models, front view.
PDB entry 2mul coloured by chain, ensemble of 20 models, side view.
PDB entry 2mul coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Farhadi S, Khatun R, Lemak A, Kaustov L, Ramabadran R, Hunter H, Sheng Y

Function and Biology Details

Reaction catalysed: 
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182301 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase HUWE1 Chain: A
Molecule details ›
Chain: A
Length: 53 amino acids
Theoretical weight: 5.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7Z6Z7 (Residues: 2951-3003; Coverage: 1%)
Gene names: HSPC272, HUWE1, KIAA0312, KIAA1578, UREB1
Sequence domains: Ubiquitin binding region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: molecular dynamics
Expression system: Escherichia coli

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