› 2mwy

Solution NMR

Mdmx-p53

Released:
DOI: 10.2210/pdb2mwy/pdb
PDB entry 2mwy coloured by chain, ensemble of 20 models, front view.
PDB entry 2mwy coloured by chain, ensemble of 20 models, side view.
PDB entry 2mwy coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
Grace CR, Ban D, Min J, Mayasundari A, Min L, Finch KE, Griffiths L, Bharatham N, Bashford D, Kiplin Guy R, Dyer MA, Kriwacki RW
J Mol Biol 428 1290-1303 (2016)
PMID: 26812210

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127313 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 10.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15151 (Residues: 23-111; Coverage: 18%)
Gene names: MDM4, MDMX
Structure domains: SWIB/MDM2 domain
Cellular tumor antigen p53 Chain: B
Molecule details ›
Chain: B
Length: 15 amino acids
Theoretical weight: 1.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 15-29; Coverage: 4%)
Gene names: P53, TP53
Sequence domains: P53 transactivation motif

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 40%
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

3 review citations

Proteasome-associated deubiquitinases and cancer.
Mofers et al. (2017)
2 more

8 mentions without citation

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept.
Uversky VN. (2016)
7 more