› 2mxc

Solution NMR

Solution structure of the full length sorting nexin 3

Released:
DOI: 10.2210/pdb2mxc/pdb
PDB entry 2mxc coloured by chain, ensemble of 20 models, front view.
PDB entry 2mxc coloured by chain, ensemble of 20 models, side view.
PDB entry 2mxc coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting.
Lenoir M, Ustunel C, Rajesh S, Kaur J, Moreau D, Gruenberg J, Overduin M
Nat Commun 9 993 (2018)
PMID: 29520003

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-129991 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sorting nexin-3 Chain: A
Molecule details ›
Chain: A
Length: 172 amino acids
Theoretical weight: 19.95 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60493 (Residues: 2-162; Coverage: 99%)
Gene name: SNX3
Sequence domains: PX domain
Structure domains: Phox-like domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

7 review citations

To degrade or not to degrade: mechanisms and significance of endocytic recycling.
Cullen et al. (2018)
6 more

4 mentions without citation

Transmembrane Membrane Readers form a Novel Class of Proteins That Include Peripheral Phosphoinositide Recognition Domains and Viral Spikes.
Overduin et al. (2022)
3 more