› 2myl

Solution NMR

Cullin3 - BTB interface: a novel target for stapled peptides

Released:
DOI: 10.2210/pdb2myl/pdb
PDB entry 2myl coloured by chain, ensemble of 20 models, front view.
PDB entry 2myl coloured by chain, ensemble of 20 models, side view.
PDB entry 2myl coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Cullin3-BTB interface: a novel target for stapled peptides.
de Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazzà D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L
PLoS One 10 e0121149 (2015)
PMID: 25848797

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171780 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cullin-3 Chain: A
Molecule details ›
Chain: A
Length: 20 amino acids
Theoretical weight: 2.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q13618 (Residues: 49-68; Coverage: 3%)
Gene names: CUL3, KIAA0617

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MK8 2 x MK8

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 46%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

3 review citations

The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update.
Lu et al. (2016)
2 more

1 mention without citation

Stapled Peptides Inhibitors: A New Window for Target Drug Discovery.
Ali et al. (2019)