› 2mz7

Solution NMR

Structure of Tau(267-312) bound to Microtubules

Released:
DOI: 10.2210/pdb2mz7/pdb
PDB entry 2mz7 coloured by chain, ensemble of 20 models, front view.
PDB entry 2mz7 coloured by chain, ensemble of 20 models, side view.
PDB entry 2mz7 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Folding of the Tau Protein on Microtubules.
Kadavath H, Jaremko M, Jaremko Ł, Biernat J, Mandelkow E, Zweckstetter M
Angew Chem Int Ed Engl 54 10347-51 (2015)
PMID: 26094605

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145370 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated protein tau Chain: A
Molecule details ›
Chain: A
Length: 46 amino acids
Theoretical weight: 4.89 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P10636 (Residues: 584-629; Coverage: 6%)
Gene names: MAPT, MAPTL, MTBT1, TAU
Sequence domains: Tau and MAP protein, tubulin-binding repeat

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 7%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

19 review citations

Tau and tauopathies.
Arendt et al. (2016)
18 more

21 mentions without citation

Amyloidogenesis of Tau protein.
Nizynski et al. (2017)
20 more