› 2n0u

Solution NMR

Mdmx-057

Released:
DOI: 10.2210/pdb2n0u/pdb
PDB entry 2n0u coloured by chain, ensemble of 20 models, front view.
PDB entry 2n0u coloured by chain, ensemble of 20 models, side view.
PDB entry 2n0u coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
Grace CR, Ban D, Min J, Mayasundari A, Min L, Finch KE, Griffiths L, Bharatham N, Bashford D, Kiplin Guy R, Dyer MA, Kriwacki RW
J Mol Biol 428 1290-1303 (2016)
PMID: 26812210

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127312 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein Mdm4 Chain: A
Molecule details ›
Chain: A
Length: 89 amino acids
Theoretical weight: 10.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O15151 (Residues: 23-111; Coverage: 18%)
Gene names: MDM4, MDMX
Structure domains: SWIB/MDM2 domain

Ligands and Environments

1 bound ligand:
Ligand 48M 1 x 48M
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 94%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

p53 Proteoforms and Intrinsic Disorder: An Illustration of the Protein Structure-Function Continuum Concept.
Uversky VN. (2016)
3 more

2 mentions without citation

Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
Grace et al. (2016)
1 more