› 2n0x

Solution NMR

Three dimensional structure of EPI-X4, a human albumin-derived peptide that regulates innate immunity through the CXCR4/CXCL12 chemotactic axis and antagonizes HIV-1 entry

Released:
DOI: 10.2210/pdb2n0x/pdb
PDB entry 2n0x coloured by chain, ensemble of 20 models, front view.
PDB entry 2n0x coloured by chain, ensemble of 20 models, side view.
PDB entry 2n0x coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and characterization of an endogenous CXCR4 antagonist.
Zirafi O, Kim KA, Ständker L, Mohr KB, Sauter D, Heigele A, Kluge SF, Wiercinska E, Chudziak D, Richter R, Moepps B, Gierschik P, Vas V, Geiger H, Lamla M, Weil T, Burster T, Zgraja A, Daubeuf F, Frossard N, Hachet-Haas M, Heunisch F, Reichetzeder C, Galzi JL, Pérez-Castells J, Canales-Mayordomo A, Jiménez-Barbero J, Giménez-Gallego G, Schneider M, Shorter J, Telenti A, Hocher B, Forssmann WG, Bonig H, Kirchhoff F, Münch J
Cell Rep 11 737-47 (2015)
PMID: 25921529

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136176 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Albumin Chain: A
Molecule details ›
Chain: A
Length: 16 amino acids
Theoretical weight: 1.83 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02768 (Residues: 432-447; Coverage: 3%)
Gene names: ALB, GIG20, GIG42, PRO0903, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696/PRO1341

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 53%
Refinement method: torsion angle dynamics

Quick links

Citations

17 review citations

New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model.
Kleist et al. (2016)
16 more

2 mentions without citation

An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation.
Harms et al. (2021)
1 more