› 2n12

Solution NMR

Solution structure of human Myosin VI isoform3 (1050-1131)

Released:
DOI: 10.2210/pdb2n12/pdb
PDB entry 2n12 coloured by chain, ensemble of 20 models, front view.
PDB entry 2n12 coloured by chain, ensemble of 20 models, side view.
PDB entry 2n12 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.
Wollscheid HP, Biancospino M, He F, Magistrati E, Molteni E, Lupia M, Soffientini P, Rottner K, Cavallaro U, Pozzoli U, Mapelli M, Walters KJ, Polo S
Nat Struct Mol Biol 23 300-308 (2016)
PMID: 26950368

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193960 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Unconventional myosin-VI Chain: A
Molecule details ›
Chain: A
Length: 82 amino acids
Theoretical weight: 9.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UM54 (Residues: 1050-1131; Coverage: 6%)
Gene names: KIAA0389, MYO6

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Unconventional Myosins: How Regulation Meets Function.
Fili et al. (2019)
1 more

4 mentions without citation

Diverse functions of myosin VI elucidated by an isoform-specific α-helix domain.
Wollscheid et al. (2016)
3 more