› 2n1i

Solution NMR

Structure of the PR domain from PRDM16

Released:
DOI: 10.2210/pdb2n1i/pdb
PDB entry 2n1i coloured by chain, ensemble of 20 models, front view.
PDB entry 2n1i coloured by chain, ensemble of 20 models, side view.
PDB entry 2n1i coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Entry authors: Sun Y, Armstrong G, Briknarova K

Function and Biology Details

Reaction catalysed: 
S-adenosyl-L-methionine + a [histone H3]-L-lysine(9) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(9)
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190731 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase PRDM16 Chain: A
Molecule details ›
Chain: A
Length: 176 amino acids
Theoretical weight: 19.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9HAZ2 (Residues: 54-226; Coverage: 14%)
Gene names: KIAA1675, MEL1, PFM13, PRDM16
Sequence domains: PR domain zinc finger protein 2, PR domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 90%
Refinement method: molecular dynamics
Expression system: Escherichia coli BL21(DE3)

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