› 2n1p

Solution NMR

Structure of the C-terminal membrane domain of HCV NS5B protein

Released:
DOI: 10.2210/pdb2n1p/pdb
PDB entry 2n1p coloured by chain, ensemble of 41 models, front view.
PDB entry 2n1p coloured by chain, ensemble of 41 models, side view.
PDB entry 2n1p coloured by chain, ensemble of 41 models, top view.
Source organism: Hepatitis C virus (isolate H)
Entry authors: Montserret R, Penin F

Function and Biology Details

Reactions catalysed: 
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151107 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
RNA-directed RNA polymerase Chain: A
Molecule details ›
Chain: A
Length: 30 amino acids
Theoretical weight: 3.48 KDa
Source organism: Hepatitis C virus (isolate H)
Expression system: Not provided
UniProt:
  • Canonical: P27958 (Residues: 2982-3011; Coverage: 1%)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 86%
Refinement method: DGSA-distance geometry simulated annealing
Expression system: Not provided

Quick links