› 2n27

Solution NMR

Competitive inhibition of TRPV1 calmodulin interaction by vanilloids

Released:
DOI: 10.2210/pdb2n27/pdb
PDB entry 2n27 coloured by chain, ensemble of 20 models, front view.
PDB entry 2n27 coloured by chain, ensemble of 20 models, side view.
PDB entry 2n27 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Competitive inhibition of TRPV1-calmodulin interaction by vanilloids.
Hetényi A, Németh L, Wéber E, Szakonyi G, Winter Z, Jósvay K, Bartus É, Oláh Z, Martinek TA
FEBS Lett 590 2768-75 (2016)
PMID: 27339229

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143908 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Calmodulin-1 Chain: A
Molecule details ›
Chain: A
Length: 148 amino acids
Theoretical weight: 16.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP23 (Residues: 2-149; Coverage: 99%)
Gene names: CALM, CALM1, CAM, CAM1
Sequence domains: EF-hand domain pair

Ligands and Environments

2 bound ligands:
Ligand CA 4 x CA
Ligand 4DY 1 x 4DY
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 67%
Refinement method: molecular dynamics
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Dawning of a new era in TRP channel structural biology by cryo-electron microscopy.
Madej et al. (2018)
3 other articles