Function and Biology Details
Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Receptor tyrosine-protein kinase erbB-2 (preferred)
PDBe Complex ID:
PDB-CPX-138084 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Receptor tyrosine-protein kinase erbB-2
Molecule details ›
Chains: A, B
Length: 58 amino acids
Theoretical weight: 6.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Epidermal growth factor receptor transmembrane-juxtamembrane segment
Length: 58 amino acids
Theoretical weight: 6.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
P04626 (Residues: 644-700; Coverage: 5%)
Sequence domains: Epidermal growth factor receptor transmembrane-juxtamembrane segment
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
Chemical shift assignment:
53%
Refinement method:
simulated annealing
Expression system: Escherichia coli
