› 2n2f

Solution NMR

Solution NMR structure of Dynorphin 1-13 bound to Kappa Opioid Receptor

Released:
DOI: 10.2210/pdb2n2f/pdb
PDB entry 2n2f coloured by chain, ensemble of 10 models, front view.
PDB entry 2n2f coloured by chain, ensemble of 10 models, side view.
PDB entry 2n2f coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure and dynamics of the agonist dynorphin peptide bound to the human kappa opioid receptor.
O'Connor C, White KL, Doncescu N, Didenko T, Roth BL, Czaplicki G, Stevens RC, Wüthrich K, Milon A
Proc Natl Acad Sci U S A 112 11852-7 (2015)
PMID: 26372966

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134108 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dynorphin A(1-13) Chain: A
Molecule details ›
Chain: A
Length: 13 amino acids
Theoretical weight: 1.61 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01213 (Residues: 207-219; Coverage: 6%)
Gene name: PDYN

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 77%
Refinement method: simulated annealing, molecular dynamics
Expression system: Not provided

Quick links

Citations

19 review citations

How Ligands Illuminate GPCR Molecular Pharmacology.
Wacker et al. (2017)
18 more

5 mentions without citation

Structural biology of human GPCR drugs and endogenous ligands - insights from NMR spectroscopy.
Ferré et al. (2020)
4 more