› 2n3y

Solution NMR

NMR structure of the Y48pCMF variant of human cytochrome c in its reduced state

Released:
DOI: 10.2210/pdb2n3y/pdb
PDB entry 2n3y coloured by chain, ensemble of 20 models, front view.
PDB entry 2n3y coloured by chain, ensemble of 20 models, side view.
PDB entry 2n3y coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of mitochondrial dysfunction in response to cytochrome c phosphorylation at tyrosine 48.
Moreno-Beltrán B, Guerra-Castellano A, Díaz-Quintana A, Del Conte R, García-Mauriño SM, Díaz-Moreno S, González-Arzola K, Santos-Ocaña C, Velázquez-Campoy A, De la Rosa MA, Turano P, Díaz-Moreno I
Proc Natl Acad Sci U S A 114 E3041-E3050 (2017)
PMID: 28348229

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161387 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome c Chain: A
Molecule details ›
Chain: A
Length: 104 amino acids
Theoretical weight: 11.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P99999 (Residues: 2-105; Coverage: 99%)
Gene names: CYC, CYCS
Sequence domains: Cytochrome c
Structure domains: Cytochrome c-like domain

Ligands and Environments

1 bound ligand:
Ligand MH0 1 x MH0
1 modified residue:
Ligand 1PA 1 x 1PA

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 88%
Refinement method: distance geometry, molecular dynamics
Expression system: Escherichia coli

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Citations

11 review citations

HIGD-Driven Regulation of Cytochrome c Oxidase Biogenesis and Function.
Timón-Gómez et al. (2020)
10 more

3 mentions without citation

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Amanzadeh et al. (2019)
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