› 2n52

Solution NMR

The solution structure of the kallikrein inhibitor SPINK6

Released:
DOI: 10.2210/pdb2n52/pdb
PDB entry 2n52 coloured by chain, ensemble of 20 models, front view.
PDB entry 2n52 coloured by chain, ensemble of 20 models, side view.
PDB entry 2n52 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The solution structure of the kallikrein-related peptidases inhibitor SPINK6.
Jung S, Fischer J, Spudy B, Kerkow T, Sönnichsen FD, Xue L, Bonvin AM, Goettig P, Magdolen V, Meyer-Hoffert U, Grötzinger J
Biochem Biophys Res Commun 471 103-8 (2016)
PMID: 26828269

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-180419 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease inhibitor Kazal-type 6 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 6.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6UWN8 (Residues: 21-80; Coverage: 100%)
Gene names: SPINK6, UNQ844/PRO1782
Sequence domains: Kazal-type serine protease inhibitor domain
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 48%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Cysteines and Disulfide Bonds as Structure-Forming Units: Insights From Different Domains of Life and the Potential for Characterization by NMR.
Wiedemann et al. (2020)
2 more

1 mention without citation

The solution structure of the kallikrein-related peptidases inhibitor SPINK6.
Jung et al. (2016)