› 2n5e

Solution NMR

The 3D solution structure of discoidal high-density lipoprotein particles

Released:
DOI: 10.2210/pdb2n5e/pdb
PDB entry 2n5e coloured by chain, ensemble of 10 models, front view.
PDB entry 2n5e coloured by chain, ensemble of 10 models, side view.
PDB entry 2n5e coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I.
Bibow S, Polyhach Y, Eichmann C, Chi CN, Kowal J, Albiez S, McLeod RA, Stahlberg H, Jeschke G, Güntert P, Riek R
Nat Struct Mol Biol 24 187-193 (2017)
PMID: 28024148

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-135985 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Truncated apolipoprotein A-I Chains: A, B
Molecule details ›
Chains: A, B
Length: 167 amino acids
Theoretical weight: 19.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02647 (Residues: 79-267; Coverage: 67%)
Gene name: APOA1
Sequence domains: Apolipoprotein A1/A4/E domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 16%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Structure and Dynamics of GPCRs in Lipid Membranes: Physical Principles and Experimental Approaches.
Jones et al. (2020)
6 more

6 mentions without citation

Dynamic protein structures in normal function and pathologic misfolding in systemic amyloidosis.
Lewkowicz et al. (2022)
5 more