› 2n64

Solution NMR

NMR Structure of the C-terminal Coiled-Coil Domain of CIN85

Released:
DOI: 10.2210/pdb2n64/pdb
PDB entry 2n64 coloured by chain, ensemble of 30 models, front view.
PDB entry 2n64 coloured by chain, ensemble of 30 models, side view.
PDB entry 2n64 coloured by chain, ensemble of 30 models, top view.
Source organism: Homo sapiens
Primary publication:
The adaptor protein CIN85 assembles intracellular signaling clusters for B cell activation.
Kühn J, Wong LE, Pirkuliyeva S, Schulz K, Schwiegk C, Fünfgeld KG, Keppler S, Batista FD, Urlaub H, Habeck M, Becker S, Griesinger C, Wienands J
Sci Signal 9 ra66 (2016)
PMID: 27353366

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-188371 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3 domain-containing kinase-binding protein 1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 75 amino acids
Theoretical weight: 8.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q96B97 (Residues: 594-665; Coverage: 11%)
Gene names: CIN85, SH3KBP1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 19%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Role of Bruton's tyrosine kinase in B cells and malignancies.
Pal Singh et al. (2018)
3 more

2 mentions without citation

Structural characterization of the self-association domain of swallow.
Loening et al. (2021)
1 more