› 2n7k

Solution NMR

Unveiling the structural determinants of KIAA0323 binding preference for NEDD8

Released:
DOI: 10.2210/pdb2n7k/pdb
PDB entry 2n7k coloured by chain, ensemble of 11 models, front view.
PDB entry 2n7k coloured by chain, ensemble of 11 models, side view.
PDB entry 2n7k coloured by chain, ensemble of 11 models, top view.
Source organism: Homo sapiens
Entry authors: Santonico E, Nepravishta R, Mattioni A, Valentini E, Mandaliti W, Procopio R, Iannuccelli M, Castagnoli L, Polo S, Paci M, Cesareni G

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127272 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
NEDD8 Chain: A
Molecule details ›
Chain: A
Length: 81 amino acids
Theoretical weight: 9.09 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q15843 (Residues: 1-81; Coverage: 100%)
Gene name: NEDD8
Sequence domains: Ubiquitin family
Protein KHNYN Chain: B
Molecule details ›
Chain: B
Length: 52 amino acids
Theoretical weight: 6.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15037 (Residues: 627-678; Coverage: 8%)
Gene names: KHNYN, KIAA0323

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 14%
Refinement method: simulated annealing
Expression system: Escherichia coli

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