› 2n9c

Solution NMR

NRAS Isoform 5

Released:
DOI: 10.2210/pdb2n9c/pdb
PDB entry 2n9c coloured by chain, ensemble of 25 models, front view.
PDB entry 2n9c coloured by chain, ensemble of 25 models, side view.
PDB entry 2n9c coloured by chain, ensemble of 25 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of NRAS isoform 5.
Markowitz J, Mal TK, Yuan C, Courtney NB, Patel M, Stiff AR, Blachly J, Walker C, Eisfeld AK, de la Chapelle A, Carson WE
Protein Sci 25 1069-74 (2016)
PMID: 26947772

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133953 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GTPase NRas Chain: A
Molecule details ›
Chain: A
Length: 20 amino acids
Theoretical weight: 2.12 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P01111 (Residues: 1-17; Coverage: 9%)
Gene names: HRAS1, NRAS

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 55%
Refinement method: torsion angle dynamics
Expression system: Not provided

Quick links

Citations

1 review citation

Splice variants of RAS-translational significance.
Rásó E. (2020)
1 other article

3 mentions without citation

5-Arylidene(chromenyl-methylene)-thiazolidinediones: Potential New Agents against Mutant Oncoproteins K-Ras, N-Ras and B-Raf in Colorectal Cancer and Melanoma.
Nastasă et al. (2019)
2 more