› 2na7

Solution NMR

Transmembrane domain of human Fas/CD95 death receptor

Released:
DOI: 10.2210/pdb2na7/pdb
PDB entry 2na7 coloured by chain, ensemble of 15 models, front view.
PDB entry 2na7 coloured by chain, ensemble of 15 models, side view.
PDB entry 2na7 coloured by chain, ensemble of 15 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis and Functional Role of Intramembrane Trimerization of the Fas/CD95 Death Receptor.
Fu Q, Fu TM, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H, Chou JJ
Mol Cell 61 602-613 (2016)
PMID: 26853147

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150478 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor receptor superfamily member 6 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 28 amino acids
Theoretical weight: 3.31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25445 (Residues: 171-198; Coverage: 9%)
Gene names: APT1, FAS, FAS1, TNFRSF6

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 8%
Refinement method: simulated annealing, molecular dynamics
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

23 review citations

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
Galluzzi et al. (2018)
22 more

8 mentions without citation

Solution NMR: A powerful tool for structural and functional studies of membrane proteins in reconstituted environments.
Puthenveetil et al. (2019)
7 more