› 2nbo

Solution NMR

Solution structure of the F87M/L110M variant of transthyretin in the monomeric state

Released:
DOI: 10.2210/pdb2nbo/pdb
PDB entry 2nbo coloured by chain, ensemble of 20 models, front view.
PDB entry 2nbo coloured by chain, ensemble of 20 models, side view.
PDB entry 2nbo coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90.
Oroz J, Kim JH, Chang BJ, Zweckstetter M
Nat Struct Mol Biol 24 407-413 (2017)
PMID: 28218749

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136163 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 13.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 81%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

8 review citations

How Plants Sense and Respond to Stressful Environments.
Lamers et al. (2020)
7 more

4 mentions without citation

Transthyretin Misfolding, A Fatal Structural Pathogenesis Mechanism.
Si et al. (2021)
3 more