› 2nbp

Solution NMR

Solution structure of the T119M variant of transthyretin in its monomeric state

Released:
DOI: 10.2210/pdb2nbp/pdb
PDB entry 2nbp coloured by chain, ensemble of 20 models, front view.
PDB entry 2nbp coloured by chain, ensemble of 20 models, side view.
PDB entry 2nbp coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Structure of Monomeric Transthyretin Carrying the Clinically Important T119M Mutation.
Kim JH, Oroz J, Zweckstetter M
Angew Chem Int Ed Engl 55 16168-16171 (2016)
PMID: 27885756

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136163 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transthyretin Chain: A
Molecule details ›
Chain: A
Length: 127 amino acids
Theoretical weight: 13.81 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P02766 (Residues: 21-147; Coverage: 100%)
Gene names: PALB, TTR
Sequence domains: HIUase/Transthyretin family
Structure domains: Transthyretin/hydroxyisourate hydrolase domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: simulated annealing
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Pathophysiology and Therapeutic Approaches to Cardiac Amyloidosis.
Griffin et al. (2021)
1 more

2 mentions without citation

Transthyretin Misfolding, A Fatal Structural Pathogenesis Mechanism.
Si et al. (2021)
1 more