› 2ndh

Solution NMR

NMR solution structure of MAL/TIRAP TIR domain (C116A)

Released:
DOI: 10.2210/pdb2ndh/pdb
PDB entry 2ndh coloured by chain, ensemble of 20 models, front view.
PDB entry 2ndh coloured by chain, ensemble of 20 models, side view.
PDB entry 2ndh coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling.
Hughes MM, Lavrencic P, Coll RC, Ve T, Ryan DG, Williams NC, Menon D, Mansell A, Board PG, Mobli M, Kobe B, O'Neill LAJ
Proc Natl Acad Sci U S A 114 E6480-E6489 (2017)
PMID: 28739909

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Toll/interleukin-1 receptor domain-containing adapter protein Chain: A
Molecule details ›
Chain: A
Length: 143 amino acids
Theoretical weight: 15.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P58753 (Residues: 79-221; Coverage: 65%)
Gene names: MAL, TIRAP
Sequence domains: TIR domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 68%
Refinement method: torsion angle dynamics
Expression system: Escherichia coli BL21

Quick links

Citations

9 review citations

Metabolic regulation of NLRP3.
Hughes et al. (2018)
8 more

4 mentions without citation

Molecular innovations in plant TIR-based immunity signaling.
Lapin et al. (2022)
3 more