› 2nld

X-ray diffraction
1.49Å resolution

Human beta-defensin-1 (Mutant Gln11Ala)

Released:
DOI: 10.2210/pdb2nld/pdb
PDB entry 2nld coloured by chain, front view.
PDB entry 2nld coloured by chain, side view.
PDB entry 2nld coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Studies of the biological properties of human beta-defensin 1.
Pazgier M, Prahl A, Hoover DM, Lubkowski J
J Biol Chem 282 1819-29 (2007)
PMID: 17071614

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-defensin 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 36 amino acids
Theoretical weight: 3.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P60022 (Residues: 33-68; Coverage: 77%)
Gene names: BD1, DEFB1, HBD1
Sequence domains: Beta defensin

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: P21
Unit cell:
a: 32.84Å b: 23.57Å c: 40.45Å
α: 90° β: 107° γ: 90°
R-values:
R R work R free
0.138 0.134 0.199
Expression system: Escherichia coli

Quick links

Citations

5 review citations

Topical antimicrobials for burn wound infections.
Dai et al. (2010)
4 more