› 2nlu

Solution NMR

Domain-Swapped Dimer of the PWWP Module of Human Hepatoma-derived Growth Factor

Released:
DOI: 10.2210/pdb2nlu/pdb
PDB entry 2nlu coloured by chain, ensemble of 16 models, front view.
PDB entry 2nlu coloured by chain, ensemble of 16 models, side view.
PDB entry 2nlu coloured by chain, ensemble of 16 models, top view.
Source organism: Homo sapiens
Primary publication:
PWWP module of human hepatoma-derived growth factor forms a domain-swapped dimer with much higher affinity for heparin.
Sue SC, Lee WT, Tien SC, Lee SC, Yu JG, Wu WJ, Wu WG, Huang TH
J Mol Biol 367 456-72 (2007)
PMID: 17270212

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156432 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hepatoma-derived growth factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 100 amino acids
Theoretical weight: 11.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P51858 (Residues: 1-100; Coverage: 42%)
Gene names: HDGF, HMG1L2
Sequence domains: PWWP domain
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Structure and function of the nucleosome-binding PWWP domain.
Qin et al. (2014)
3 more

2 mentions without citation

PWWP domains and their modes of sensing DNA and histone methylated lysines.
Rona et al. (2016)
1 more