› 2nmn

X-ray diffraction
2.45Å resolution

Crystal structure of human galectin-3 carbohydrate-recognising domain at 2.45 angstrom resolution

Released:
DOI: 10.2210/pdb2nmn/pdb
PDB entry 2nmn coloured by chain, front view.
PDB entry 2nmn coloured by chain, side view.
PDB entry 2nmn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Slow diffusion of lactose out of galectin-3 crystals monitored by X-ray crystallography: possible implications for ligand-exchange protocols.
Collins PM, Hidari KI, Blanchard H
Acta Crystallogr D Biol Crystallogr 63 415-9 (2007)
PMID: 17327679

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148215 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Galectin-3 Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 15.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P17931 (Residues: 113-250; Coverage: 55%)
Gene names: LGALS3, MAC2
Sequence domains: Galactoside-binding lectin
Structure domains: Jelly Rolls

Ligands and Environments

Carbohydrate polymer : NEW Components: BGC, GAL
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MACSCIENCE
Spacegroup: P212121
Unit cell:
a: 37.341Å b: 58.238Å c: 63.731Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.167 0.163 0.237
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Dynamics of galectin-3 in the nucleus and cytoplasm.
Haudek et al. (2010)
6 more

2 mentions without citation

Dual thio-digalactoside-binding modes of human galectins as the structural basis for the design of potent and selective inhibitors.
Hsieh et al. (2016)
1 more