› 2noj

X-ray diffraction
2.7Å resolution

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133848 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Complement C3d fragment Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 297 amino acids
Theoretical weight: 33.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01024 (Residues: 996-1287; Coverage: 18%)
Gene names: C3, CPAMD1
Sequence domains: A-macroglobulin TED domain
Structure domains: Glycosyltransferase
Efb homologous protein Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 80 amino acids
Theoretical weight: 9.6 KDa
Source organism: Staphylococcus aureus subsp. aureus Mu50
Expression system: Escherichia coli BL21(DE3)
Structure domains: Sbi, C3 binding domain IV

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 67.894Å b: 91.025Å c: 122.595Å
α: 90° β: 89.93° γ: 90°
R-values:
R R work R free
0.29 0.291 0.284
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

15 review citations

Complement System Part II: Role in Immunity.
Merle et al. (2015)
14 more

6 mentions without citation

Complement evasion by human pathogens.
Lambris et al. (2008)
5 more