› 2npq

X-ray diffraction
1.8Å resolution

A Novel Lipid Binding Site in the p38 alpha MAP Kinase

Released:
DOI: 10.2210/pdb2npq/pdb
PDB entry 2npq coloured by chain, front view.
PDB entry 2npq coloured by chain, side view.
PDB entry 2npq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A novel lipid binding site formed by the MAP kinase insert in p38 alpha.
Diskin R, Engelberg D, Livnah O
J Mol Biol 375 70-9 (2008)
PMID: 17999933

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 367 amino acids
Theoretical weight: 42.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16539 (Residues: 2-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand BOG 2 x BOG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: P212121
Unit cell:
a: 68.607Å b: 74.212Å c: 74.571Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.203 0.245
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Molecular dynamics-driven drug discovery: leaping forward with confidence.
Ganesan et al. (2017)
7 more

6 mentions without citation

CryptoSite: Expanding the Druggable Proteome by Characterization and Prediction of Cryptic Binding Sites.
Cimermancic et al. (2016)
5 more