› 2nru

X-ray diffraction
2Å resolution

Crystal structure of IRAK-4

Released:
DOI: 10.2210/pdb2nru/pdb
PDB entry 2nru coloured by chain, front view.
PDB entry 2nru coloured by chain, side view.
PDB entry 2nru coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structures of IRAK-4 kinase in complex with inhibitors: a serine/threonine kinase with tyrosine as a gatekeeper.
Wang Z, Liu J, Sudom A, Ayres M, Li S, Wesche H, Powers JP, Walker NP
Structure 14 1835-44 (2006)
PMID: 17161373

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192669 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interleukin-1 receptor-associated kinase 4 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 307 amino acids
Theoretical weight: 34.58 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: Q9NWZ3 (Residues: 154-460; Coverage: 67%)
Gene name: IRAK4
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 2 x SO4
Ligand T12 4 x T12
2 modified residues:
Ligand TPO 4 x TPO
Ligand SEP 4 x SEP

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: C2
Unit cell:
a: 145.303Å b: 141.292Å c: 88.423Å
α: 90° β: 125.8° γ: 90°
R-values:
R R work R free
0.237 0.233 0.299
Expression system: unidentified baculovirus

Quick links

Citations

15 review citations

Targeting innate immunity protein kinase signalling in inflammation.
Gaestel et al. (2009)
14 more

32 mentions without citation

IRAK-4 inhibitors for inflammation.
Wang et al. (2009)
31 more