› 2nsu

Electron Microscopy
27Å resolution

Crystal structure of the ectodomain of human transferrin receptor fitted into a cryo-EM reconstruction of canine parvovirus and feline transferrin receptor complex

Released:
DOI: 10.2210/pdb2nsu/pdb
PDB entry 2nsu coloured by chain, front view.
PDB entry 2nsu coloured by chain, side view.
PDB entry 2nsu coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Asymmetric binding of transferrin receptor to parvovirus capsids.
Hafenstein S, Palermo LM, Kostyuchenko VA, Xiao C, Morais MC, Nelson CD, Bowman VD, Battisti AJ, Chipman PR, Parrish CR, Rossmann MG
Proc Natl Acad Sci U S A 104 6585-9 (2007)
PMID: 17420467
Related structures: EMD-1288

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136213 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transferrin receptor protein 1, serum form Chains: A, B
Molecule details ›
Chains: A, B
Length: 639 amino acids
Theoretical weight: 71.62 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P02786 (Residues: 122-760; Coverage: 84%)
Gene name: TFRC
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 27Å
Relevant EMDB volumes: EMD-1288
Expression system: Cricetulus griseus

Quick links

Citations

15 review citations

Twenty-Five Years of Structural Parvovirology.
Mietzsch et al. (2019)
14 more

5 mentions without citation

Asymmetric binding of transferrin receptor to parvovirus capsids.
Hafenstein et al. (2007)
4 more