2ny7

X-ray diffraction
2.3Å resolution

HIV-1 gp120 Envelope Glycoprotein Complexed with the Broadly Neutralizing CD4-Binding-Site Antibody b12

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
hetero hexamer
PDBe Complex ID:
PDB-CPX-208534 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Surface protein gp120 Chain: G
Molecule details ›
Chain: G
Length: 317 amino acids
Theoretical weight: 35.13 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Homo sapiens
UniProt:
  • Canonical: P04578 (Residues: 83-492; Coverage: 39%)
Gene name: env
Sequence domains: Envelope glycoprotein GP120
Structure domains: Human immunodeficiency virus 1, Gp160, envelope glycoprotein
ANTIBODY b12, HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 230 amino acids
Theoretical weight: 24.91 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins
Immunoglobulin kappa constant Chain: L
Molecule details ›
Chain: L
Length: 215 amino acids
Theoretical weight: 23.71 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P01834 (Residues: 1-107; Coverage: 100%)
Gene name: IGKC
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P6522
Unit cell:
a: 101.955Å b: 101.955Å c: 298.294Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.196 0.193 0.255
Expression systems:
  • Homo sapiens
  • Cricetulus griseus