› 2nz7

X-ray diffraction
1.9Å resolution

Crystal Structure Analysis of Caspase-recruitment Domain (CARD) of Nod1

Released:
DOI: 10.2210/pdb2nz7/pdb
PDB entry 2nz7 coloured by chain, front view.
PDB entry 2nz7 coloured by chain, side view.
PDB entry 2nz7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Monomer/dimer transition of the caspase-recruitment domain of human Nod1.
Srimathi T, Robbins SL, Dubas RL, Hasegawa M, Inohara N, Park YC
Biochemistry 47 1319-25 (2008)
PMID: 18186648

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195095 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleotide-binding oligomerization domain-containing protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 98 amino acids
Theoretical weight: 11.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Y239 (Residues: 9-106; Coverage: 10%)
Gene names: CARD4, NOD1
Sequence domains: Caspase recruitment domain
Structure domains: Death Domain, Fas

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P3121
Unit cell:
a: 79.091Å b: 79.091Å c: 80.863Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.222 0.22 0.266
Expression system: Escherichia coli

Quick links

Citations

5 review citations

NLR functions in plant and animal immune systems: so far and yet so close.
Maekawa et al. (2011)
4 more

18 mentions without citation

Structural mechanisms in NLR inflammasome signaling.
Lechtenberg et al. (2014)
17 more