› 2o0o

X-ray diffraction
3Å resolution

Crystal structure of TL1A

Released:
DOI: 10.2210/pdb2o0o/pdb
PDB entry 2o0o coloured by chain, front view.
PDB entry 2o0o coloured by chain, side view.
PDB entry 2o0o coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
X-ray crystal structure of TNF ligand family member TL1A at 2.1A.
Jin T, Guo F, Kim S, Howard A, Zhang YZ
Biochem Biophys Res Commun 364 1-6 (2007)
PMID: 17935696

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131828 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tumor necrosis factor ligand superfamily member 15, secreted form Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 180 amino acids
Theoretical weight: 20.5 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O95150 (Residues: 72-251; Coverage: 72%)
Gene names: TL1, TNFSF15, VEGI
Sequence domains: TNF(Tumour Necrosis Factor) family
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P41212
Unit cell:
a: 116.754Å b: 116.754Å c: 118.941Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.256 0.243 0.295
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Structural principles of tumor necrosis factor superfamily signaling.
Vanamee et al. (2018)
5 more

1 mention without citation

Biochemical and structural characterization of the human TL1A ectodomain.
Zhan et al. (2009)